Maximize the Influence of Biomaterials in Tissue Engineering and Regenerative Medicine: Learn from Nature
Monday 3rd July 2017 - 18:15 - Westminster Theatre
Maximize the Influence of Biomaterials in Tissue Engineering and Regenerative Medicine:
Learn from Nature
Regenerative medicine and tissue engineering have enabled the generation of functional organs or tissues outside the human body intended for implantation back into patients. It has further allowed the regeneration of particular damaged tissues within the body, which usually does not occur naturally. Among other factors to realize these challenges, one needs to create supportive artificial extracellular matrix which not only acts as physical scaffolds to dwell the cells which are the essential element in developing tissues, but also is the key location, rich in signals in controlling and regulating the intensive communication between cells. The signals include biological molecules, topographic features and strength of the matrix. Learning from the native extracellular matrix, biomaterials can be fabricated into artificial extracellular matrix, allowing the delivery of regeneration signals accurately and optimally. This lecture will highlight the new techniques which have been developed to replicate such extracellular matrix in specific tissue generation, for example, induction of cell orientation/assembly, target protein synthesis and the detection of cellular responses to the matrix.
Ying Yang is a Professor in Biomaterials and Tissue Engineering. She obtained her PhD at Manchester University in Materials Science and Technology and joined Keele University in 1997. The broad engineering and material background assist the converging her research to biomaterials and Tissue Engineering field effectively. Working closely with biologists and clinicians, she manipulates biomaterials, particularly in nanofibers and hydrogels to maximize artificial matrix’s influence in multiple tissue models including eye, tendon, bone, cartilage, skin and nerve. These models serve as drug screening, cell therapy validation and potential tissue grafting. The knowledge and research of the extracellular matrix mutually supports her research in multiple connective tissue related diseases as well.